S. aureus enhances replication of SARS-CoV-2 in vitro through the bacterial iron-regulated surface determinant protein A

In a recent study published in iScience, researchers assessed the impact of Staphylococcus aureus (S. aureus) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication.

Study: The Staphylococcus aureus protein IsdA increases SARS CoV-2 replication by modulating JAK-STAT signaling. Image Credit: Kateryna Kon/Shutterstock


S. aureus has been identified as a common secondary bacterial coinfection agent for different respiratory viruses. Several investigations have revealed that coinfection with the influenza A virus (IAV) led to more severe dysregulation of the immune system, such as the destruction of alveolar macrophages.

Studies have also described the on-immune mechanisms at the molecular level as IAV infection increases the adherence of S. aureus to epithelial cells and elevates intracellular bacterial reproduction.

In contrast, the S. aureus protein…

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