Probiotic markedly reduces S. aureus colonization in Phase 2 trial

News Release

Tuesday, January 17, 2023

NIH study provides new insights on role of gut in staph colonization.

A promising approach to control Staphylococcus aureus bacterial colonization in people – using a probiotic instead of antibiotics – was safe and highly effective in a Phase 2 clinical trial. The new study, reported in The Lancet Microbe, found that the probiotic Bacillus subtilis markedly reduced S. aureus colonization in trial participants without harming the gut microbiota, which includes bacteria that can benefit people. The research was conducted by researchers at the National Institutes of Health led by Michael Otto, Ph.D., an NIH senior investigator at the National Institute of Allergy and Infectious Diseases (NIAID).

Methicillin-resistant S. aureus, or MRSA, is familiar to many people as a cause of serious disease. Less well known is that S. aureus often lives in the nose,…

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